Cardiovascular Metabolomics
نویسندگان
چکیده
منابع مشابه
Metabolomics and cardiovascular biomarker discovery.
BACKGROUND Metabolomics, the systematic analysis of low molecular weight biochemical compounds in a biological specimen, has been increasingly applied to biomarker discovery. CONTENT Because no single analytical method can accommodate the chemical diversity of the entire metabolome, various methods such as nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) have been empl...
متن کاملMetabolomics in Cardiovascular Disease: Towards Clinical Application
Metabolomics were initially defined as the global analysis of all metabolites present in a sample (metabolomics) and the analysis of metabolic responses to drugs and diseases (metabonomics) [Nicholson et al., 1999, Fiehn 2002, Weckwerth and Morgenthal 2005]. These two definitions have an historical origin, while metabolomics has its foundations in microbial and plant sciences metabonomics origi...
متن کاملRecent highlights of metabolomics in cardiovascular research.
American Heart Association. All rights reserved. Print ISSN: 1942-325X. Online ISSN: 2011 Copyright © Avenue, Dallas, TX 72514 Circulation: Cardiovascular Genetics is published by the American Heart Association. 7272 Greenville DOI: 10.1161/CIRCGENETICS.111.961003 2011;4;463-464; Circ Cardiovasc Genet Manuel Mayr Recent Highlights of Metabolomics in Cardiovascular Research http://circgenetics.a...
متن کاملApplication of metabolomics to cardiovascular biomarker and pathway discovery.
Emerging technologies based on mass spectrometry and nuclear magnetic resonance enable the monitoring of hundreds of metabolites from tissues or body fluids, that is, "metabolomics." Because metabolites change rapidly in response to physiologic perturbations, they represent proximal reporters of disease phenotypes. The profiling of low molecular weight biochemicals, including lipids, sugars, nu...
متن کاملCardiovascular Genetics: A News Round-Up Recent Highlights of Metabolomics in Cardiovascular Research
1. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WH, DiDonato JA, Lusis AJ, Hazen SL. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472:57–63. 2. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O’Donne...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2018
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.117.311002